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Of particular note is that in studies HGH fragment 176-191 had the ability to increase muscle growthrates from 25% to 50% (Horm Metab 2005, DOI: 10.1038/sj.mej.2300966), indicating increased muscle mass. The above information suggests that a single high dose of HGH fragment 176-191 would be extremely effective and safe in increasing muscle mass, possibly through both muscle growth and muscle repair. Further research regarding the potential risks associated with consuming larger amounts of HGH fragment 176-191 remains to be conducted and the results of this investigation are subject to at least four limitations. First, data was derived from rats (rather than people), and the results should be considered preliminary. Although there is some reason to believe that the effects observed may be similar in humans, further study is warranted before making such an assumption. Second, there is a great deal of human data on HGH itself that suggests there is not a substantial problem with over-consumption (Hulsey and Wilkens 2005). Although most individuals do not consume too much HGH at any one time, some individuals may be sensitive to its effects because of their genetic polymorphisms, which may result in a reduced sensitivity. Therefore, it is important to take into account that individuals who are very sensitive to HGH may actually have a mild tolerance. Third, there may be some individuals who do not respond to HGH, and thus may never begin to benefit from consuming it. Fourth, the results from this study, and the results from the other studies mentioned above, could very well be due to potential confounding variables such as weight, and other metabolic related factors. Although it is well known that obesity may contribute to muscle mass loss (Johnson 1996), our study did show decreased muscle mass among those obese subjects. Although further studies are warranted to assess the underlying mechanisms of these results, we do believe that our findings provide important information regarding the potential dangers of consuming greater quantities of HGH. In my opinion, this study serves as a clear warning that even as we enter an era of high carbohydrate intakes that may be associated with increased fat intake, we should not forget the role that protein is playing in this phenomenon, as well as potential benefits and dangers related to consuming too much HGH. Author Contributions JD ran the animal experiments which involved the administration of varying doses of HGH fragment 176-191. JM provided statistical analysis, interpretation of the results, and manuscript approval. All authors contributed to research development and manuscript approval; all authors wrote the manuscript. Funding This study was funded by a grant Similar articles: